* Cardiovascular Imaging Laboratory *
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Physician Photo
Pablo Soto, M.D.
Instructor in Medicine, Cardiovascular Division
Office: East Building 1300
Tel: 314.747.3888
Fax: 314.747.3882
sotop@mir.wustl.edu
 
Dept of Radiology
Washington University
Campus Box 8225
510 S. Kinshighway Blvd
St. Louis, MO 63130

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Mentor: Robert J. Gropler, MD - "Impact of Aging on Myocardial Metabolic Remodeling: Role of Nitric Oxide"

Curriculum Vitae

CURRENT POSITION

Instructor in Medicine, Cardiovascular Division
Washington University School of Medicine, St. Louis, Missouri

EDUCATION AND TRAINING

2004-present
Instructor in Medicine, Cardiovascular Division, Wash U. School of Medicine
2001-2004
Research Fellow, Cardiovascular Division, Washington U. School of Medicine
1999-2001
Barnes-Jewish Hospital, Clinical Fellow in Cardiology
1996-1999
University of Michigan Medical Center, Resident in Internal Medicine
1991-1994
Columbia-Presbyterian Medical Center, Resident in General Surgery
1987-1991
Duke University School of Medicine, MD 1991
1983-1987
Princeton University, BSE 1987, Aerospace Engineering, Cum Laude Graduate

PRIOR RESEARCH EXPERIENCE

1994-1996
Cardiovascular Research Fellow
Department of Surgery, Columbia University, New York, NY
Mentor: Henry M. Spotnitz, MD
Project: Role of Ventricular Compliance in Acute Allograft Rejection
1989-1990
Medical Student
Department of Surgery, Duke University School of Medicine
Mentor: J. Scott Rankin, MD
Project: Arterial Windkessel Modeling
1986-1987
Undergraduate
Department of Mechanical and Aerospace Engineering, Princeton University
Mentor: Richard B. Miles, PhD
Project: 3-D MRI Reconstruction
1985
Summer Undergraduate Research Fellow
Department of Biochemistry, University of Alabama at Birmingham
Mentor: Kenneth B. Taylor, PhD
Project: Optimal Harvesting Techniques for Bacterial Cultures

RESEARCH SUPPORT - CURRENT AND PRIOR

Granting Agency:
National Institutes of Health, Mentored Patient-Oriented Research Career Development Award
1 K23 HL077179-01
Role:
Principal Investigator
Title:
"Role of Estrogen/SERMs on Cardiac Fatty Acid Metabolism"
Duration:
9/30/2004 to 8/31/2009

Granting Agency:
American Heart Association, Heartland Affiliate Postdoctoral Fellowship
0225573Z
Role:
Principal Investigator
Title:
"Impact of Aging on Myocardial Metabolic Remodeling: Role of Nitric Oxide"
Duration:
7/1/2002 to 6/30/2004

Granting Agency:
National Institutes of Health, National Research Service Award Postdoctoral Fellowship
1 F32 HL09356-01
Role:
Principal Investigator
Title:
"Left Ventricular Compliance in Acute Allograft Rejection"
Duration:
7/1/1995 to 6/30/1996
Total Cost:
$31,200

PRESENTATIONS AT NATIONAL MEETINGS

  1. Improved Aerobic Capacity with Exercise Training in the Elderly Correlates with Increased Myocardial Fatty Acid Uptake During Dobutamine. 50th Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA; June 24, 2003.

  2. Impact of Estrogen on Myocardial Fatty Acid Utilization and Oxidation in Postmenopausal Women -
    AstraZeneca Cardiovascular Young Investigator's Forum, San Francisco, CA; Oct 11, 2002.

  3. Effect of Inducible Nitric Oxide Synthase Inhibition on Diastolic Properties of the Rejecting Rat Heart -
    72nd Scientific Session, American Heart Association, New Orleans, LA, Nov 16, 1996.

  4. Timing of Pre-Transplantation Cyclosporine Affects Left Ventricular Function in the Rat -
    Experimental Biology, Washington, DC, May 12, 1996.

  5. Diastolic Properties During Rejection of the Heterotopically Transplanted Rat Heart -
    81st Annual Clinical Congress, American College of Surgeons, New Orleans, October 11, 1995.

HONORS

2004
Burton E. Sobel Award for Excellence in Cardiovascular Research - Washington Univ.
2002
Finalist, AstraZeneca Cardiovascular Young Investigator's Forum
1987
Cum Laude Graduate, Princeton University
1987
The Donald Janssen Dike Award for Excellence in Undergraduate Research - 2nd Prize.
1985
Tau Beta Pi Engineering Honor Society - Treasurer

LICENSES AND BOARD CERTIFICATIONS

2000-present
Missouri Medical License #2000175095
1998-present
Michigan Medical License #4301068054
1994-1998
New York Medical License #194669

2000
Diplomate, American Board of Internal Medicine
2002
Diplomate, Cardiovascular Diseases
2003
Testamur, Adult Echocardiography, National Board of Echocardiography
2003
Certification Board of Nuclear Cardiology

Publications - Manuscripts

  1. Herrero P, Soto PF, Ware Z, Delano DA, Gropler RJ. Impact of hormone replacement on myocardial fatty acid metabolism: potential role of estrogen. (In Review)

  2. Gropler RJ and Soto PF. Recent advances in cardiac positron emission tomography in the clinical management of the cardiac patient. Curr Cardiol Rep 2004;6(1):20-6.

  3. Soto PF, Herrero P, Kates AM, Dence C, Ehsani AA, Davila-Roman V, Schectmann KB, Gropler RJ. Impact of aging on myocardial metabolic response to dobutamine. Amer J Physiol: Heart and Circulatory Physiology 2003;285:H2158-2164.

  4. Kates AM, Herrero P, Dence C, Soto PF, Srinivasan M, Delano D, Ehsani A, Gropler RJ. Impact of Aging on Substrate Metabolism by the Human Heart. J Amer Coll Cardiol2003;41(2):293-299.

  5. Soto PF, Kovacs SJ. The Diagnosis and Treatment of Diastolic Heart Failure. Cardiovascular Reviews and Reports 2002;23(9):493-500.

  6. Soto PF, Jia CX, Rabkin DA, Carter YM, Sardo MJ, Hsu DT, Fisher DT, Pinsky D, Spotnitz HM. Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition. J Thorac Cardiovasc Surg 2000;120:39-46.

  7. Starr JP, Jia CX, Rabkin DA, Amirhamzeh MM, Hart JP, Hsu DT, Soto P, Pinsky D, Spotnitz HM. Pressure volume curves in arrested heterotopic rat heart isografts: role of improved myocardial protection. J Surgical Res 1999;86(1):123-9.

  8. Soto PF, Jia CX, Carter YM, Rabkin D, Starr JP. Amirhamzeh MM, Hsu DT, Sciacca R, Fisher PE, Spotnitz HM. Effect of improved myocardial protection on edema and diastolic properties of the rat left ventricle during acute allograft rejection. J Heart Lung Transplant 1998;17(6):608-16.

  9. Cabreriza SE, Dean DA, Amirhamzeh MM, Jia CX, Sciacca R, Soto P, Spotnitz HM. A method for detecting changes in left ventricular mass during variations in filling volume. J Am Soc Echocardiogr 1998;11(4):356-64.

  10. Carter YM, Jia CX, Soto PF, Starr JP, Rabkin DG, Hsu DT, Fisher PE, Spotnitz HM. Diastolic properties, myocardial water content, and histologic condition of the rat left ventricle: effect of varied osmolarity of a coronary perfusate. J Heart Lung Transplant 1998;17(2):140-9.

  11. Dean DA, Jia CX, Cabreriza SE, Soto PF, Rabkin DG, Sardo MJ, Chalik N, Spotnitz HM. Retrograde coronary perfusion: effects on iatrogenic edema and diastolic properties. Ann Thorac Surg 1998;65(2):449-5.

  12. Soto PF, Jia CX, Carter YC, Starr JP, Amirhamzeh MMR, Spotnitz HM. Diastolic properties during rejection of the heterotopically transplanted rat heart. Surg Forum 1995;46:452-55.

  13. Shim Y, Pasipoularides A, Straley CA, Hampton TG, Soto PF, Owen CH, Davis JW, Glower DD. Arterial windkessel parameter estimation: a new time-domain method. Ann Biomed Engineering 1994;22(1):66-7.

Publications - Abstracts

  1. Soto PF, Herrero P, Baumstark JM, DeLano DA, Ehsani AA, Gropler RJ. Improved Aerobic Capacity with Exercise Training in the Elderly Correlates with Increased Myocardial Fatty Acid Uptake During Dobutamine. J Nuc Med (suppl.) 2003;44(5):106P.

  2. Soto PF, Singh J, Lisauskas J, Meyer TE, Ehsani AA, Kovacs SJ. The relation of aerobic exercise capacity (peak VO2) to Doppler E-wave derived indexes of diastolic function in patients with advanced heart failure. Circulation (suppl.) 2001;104(17):II-411.

  3. Soto PF, Jia CX, Sardo MJ, Fisher PE, Spotnitz HM. Effect of nitric oxide synthase inhibition on diastolic properties of the rejecting rat heart. Circulation (suppl.) 1996;94(8):I-590.
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